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目的:评价硝黄汤鼻饲联合灌肠对ICU重症患者肠屏障功能障碍的影响。方法:将40例肠屏障功能障碍患者随机分为两组,分别于治疗前及治疗1 d、3 d及5 d观察患者肠鸣音、APACHEⅡ评分,检测DAO、IFABP及内毒素水平,记录患者ICU住院天数,试验组20例,给予一般治疗的基础上,在第1天留取试验标本后即在常规治疗的同时开始给予硝黄汤鼻饲联合灌肠,对照组给予常规治疗。结果:治疗前两组肠鸣音、APACHEⅡ评分、DAO、IFABP及内毒素水平差异无统计学意义(P>0.05);经硝黄汤鼻饲联合灌肠治疗后1 d、3 d、5 d,试验组的肠鸣音、APACHEⅡ评分、DAO、IF-ABP及内毒素水平较对照组明显降低(P<0.05)。结论:硝黄汤鼻饲联合灌肠能改善ICU重症患者肠屏障功能障碍。
Objective: To evaluate the effect of rhubarb soup nasal feeding combined with enema on gut barrier dysfunction in critically ill patients with ICU. Methods: Forty patients with gut barrier dysfunction were randomly divided into two groups. The bowel sounds, APACHEⅡscore, DAO, IFABP and endotoxin levels were observed before treatment, 1 day, 3 days and 5 days after treatment respectively. The patients were recorded ICU hospitalization days, the experimental group of 20 patients, given the general treatment, based on the first day after taking the test specimens, namely in the conventional treatment at the same time began to give rhubarb soup nasal feeding combined enema, the control group given routine treatment. Results: There was no significant difference in bowel sounds, APACHEⅡscore, DAO, IFABP and endotoxin levels between the two groups before treatment (P> 0.05). On the 1st day, 3rd day and 5th day after nasal feeding, Bowel sounds, APACHEⅡscore, DAO, IF-ABP and endotoxin levels were significantly lower than the control group (P <0.05). Conclusion: Nantou soup combined with nasal feeding enema can improve intestinal barrier dysfunction in ICU critically ill patients.