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采用敏感性、特异性均较高的特异性抗哇巴因抗体酶联免疫吸附法（ＥＬＩＳＡ法）对２０例肾功正常的原发性肾病综合征患者血清内源性哇巴因（Ｅｎｄｏｇｅ－ｎｏｕｓｏｕａｂａｉｎ，ＥＯ）水平进行测定。发现肾功正常的原发性肾病综合征患者血清ＥＯ水平显著高于正常对照组，有高血压的肾病综合征患者血清ＥＯ水平显著高于无高血压组。结果表明ＥＯ在原发性肾病综合征的发生发展及肾性高血压的产生和维持中起一定作用。
The specific anti-ouabain antibody ELISA method was used to detect the endogenous endovanuin-induced endothelin in 20 patients with primary nephrotic syndrome with normal renal function. nousouabain, EO) levels were measured. Found that patients with normal renal function nephrotic syndrome serum EO levels were significantly higher than the normal control group, patients with hypertension nephrotic syndrome serum EO levels were significantly higher than those without hypertension. The results show that EO play a role in the occurrence and development of primary nephrotic syndrome and the generation and maintenance of renal hypertension.