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观察钙调素拮抗剂氯丙嗪（ Ｃ Ｐ Ｚ） 和钙离子通道阻断剂尼莫地平（ Ｎ Ｉ Ｍ Ｏ） 以及同时给予以上两药对镉（ Ｃｄ） 致小鼠肝、肾毒作用的保护作用。利用模拟镉中毒动物模型。实验组预先灌胃给予小鼠 Ｃ Ｐ Ｚ、 Ｎ Ｉ Ｍ Ｏ、 Ｃ Ｐ Ｚ＋ Ｎ Ｉ Ｍ Ｏ，１ 小时后以１／５ Ｌ Ｄ－ ５０ Ｃｄ Ｃｌ２ 腹腔注射，连续五天，第六天收集生物样本检测各项指标。结果表明， Ｃ Ｐ Ｚ 能明显降低血镉，降低尿中ｒ － Ｇ Ｔ 及 Ｎ Ａ Ｇ 活性。 Ｃ Ｐ Ｚ和 Ｎ Ｉ Ｍ Ｏ 对于镉引起的钙泵活性降低，均表现出明显的保护作用，两药合用作用增强。 Ｃ Ｐ Ｚ 和 Ｎ Ｉ Ｍ Ｏ 均能显著提高镉中毒小鼠肝、肾组织中镉金属硫蛋白（ Ｍ Ｔ） 含量。揭示这两种钙拮抗剂对小鼠镉中毒肝、肾毒效应均有防护作用。 Ｃ Ｐ Ｚ 比 Ｎ Ｉ Ｍ Ｏ 明显。这两种药物合用在某些方面起协同作用。该两药的防护作用可能与 Ｍ Ｔ 参与有关。
To observe the effects of calmodulin antagonist chlorpromazine (C P Z) and calcium channel blocker (N I M O) and simultaneous administration of the above two drugs on liver and kidney of mice induced by cadmium (Cd) Protective effects. Using simulated cadmium poisoning animal model. The experimental group was given intragastric administration of C P Z, N I M O and C P Z + N I M O by gavage. One hour later, the mice were injected intraperitoneally with 1/5 L D-50 Cd Cl2 for five days on the sixth day Sample testing indicators. The results showed that C P Z can significantly reduce blood cadmium, reduce urinary r - G T and N A G activity. Both C P Z and N I M O showed a significant protective effect on the decrease of calcium pump activity caused by cadmium, and their combination effect was enhanced. Both C P Z and N I M O could significantly increase the content of cadmium metallothionein (M T) in the liver and kidney of cadmium-poisoned mice. Reveal these two kinds of calcium antagonists on mice cadmium poisoning liver and kidney effects have protective effect. C P Z is more pronounced than N I M O. The combination of these two drugs act synergistically in some ways. The protective effect of the two drugs may be related to M T participation.