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目的 :分析抗甲状腺药物(ATD)引起粒细胞缺乏症(粒缺)的原因、危害 ,提出防治措施。方法 :对5年来16例因ATD引起的粒缺住院患者临床资料进行回顾性分析。结果 :ATD引起粒缺多发生于服药后2～12周 ,起病时多伴有发热、咽痛、乏力等症状 ,糖皮质激素合并惠尔血(rhGM_CSF)组治疗血白细胞恢复时间比单纯应用激素组或单纯应用惠尔血组缩短。结论 :ATD治疗过程中应密切监测血白细胞 ,尽早发现粒缺患者 ,及时采取防治感染、升白细胞等综合治疗措施
Objective: To analyze the cause and harm of agranulocytosis caused by antithyroid drug (ATD), and put forward the prevention and cure measures. Methods: A retrospective analysis was performed on the clinical data of 16 patients with stenosis due to ATD in 5 years. RESULTS: The majority of ATD-induced granulosa occurred in 2 to 12 weeks after treatment. The symptoms of fever, sore throat and fatigue were often found in patients with ATD. The recovery time of white blood cells treated with glucocorticoid combined with rhGM_CSF was significantly higher than that of simple application Hormone group or simple application of shortened blood group. Conclusion: During the course of treatment of ATD, white blood cells should be closely monitored, and the patients with granulomatous deficiency should be detected as soon as possible, and the comprehensive treatment measures such as infection prevention and white blood cell improvement should be adopted in time