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各种病因引起的心力衰竭是临床上常遇到的问题之一。1956年Burch首次采用血管扩张剂六甲季胺(Hexamethonium)静脉注射,使肺水肿迅速缓解。但由于当时一些心脏病学家的注意力集中在心肌收缩力与血容量上,对血管扩张剂治疗心力衰竭的作用未能予以正确地评价。近年对血液动力学研究的结果表明,心功能还取决于周围动脉和静脉床的动力学,为血管扩张剂的应用提供了理论基础。
Heart failure caused by various causes is one of the problems often encountered clinically. 1956 Burch for the first time using intravenous injection of hexamethonium vasodilator, pulmonary edema quickly relieved. However, at that time, some cardiologists focused their attention on myocardial contractility and blood volume, failing to evaluate the effect of vasodilator on heart failure. In recent years, the results of hemodynamic studies show that cardiac function also depends on the dynamics of peripheral arterial and venous beds, providing a theoretical basis for the application of vasodilators.