目的　研究瘦素与酒精性肝病 (ALD)肝纤维化发生发展的关系。方法　用ELISA方法检测 6 0例ALD患者血清瘦素水平 ,16位健康人作为对照组 ,同步检测了ALD患者的血清肝纤维化指标HA、LN、PCⅢ及TGFβ1,对血清瘦素与肝纤维化指标、肝组织纤维化分期间的关系进行了分析。结果　ALD患者的血清瘦素水平明显高于对照组 ,在酒精性脂肪肝 (AFL)、酒精性肝炎 (AH)、酒精性肝硬化 (ALC)瘦素水平依次增高 ,差异有显著性。在AH、ALC血清瘦素水平与肝纤维化血清学指标和TGFβ1正相关 ,ALD患者的血清瘦素水平与肝组织纤维化分期密切相关。结论　血清瘦素是ALD患者肝纤维化的始动因子之一。 Objective To study the relationship between leptin and hepatic fibrosis in patients with alcoholic liver disease (ALD). Methods The levels of serum leptin in 60 patients with ALD were detected by ELISA and the serum levels of HA, LN, PC Ⅲ and TGFβ1 were detected simultaneously in 16 ALD patients and 16 healthy subjects as controls. Serum leptin and liver fibrosis Indicators, liver fibrosis stages were analyzed. Results Serum leptin levels in patients with ALD were significantly higher than those in controls. The levels of leptin in alcoholic fatty liver (AFL), alcoholic hepatitis (AH) and alcoholic liver cirrhosis (ALC) were significantly higher than those in controls. Serum leptin levels in ALC were positively correlated with serum fibrotic markers and TGFβ1 in AH. Serum leptin levels in patients with ALD were closely related to liver fibrosis stage. Conclusion Serum leptin is one of the initiators of hepatic fibrosis in patients with ALD.