自从Friendenstein发现并证实骨髓中存在一种可贴壁生长的纺锤形的成纤维细胞集落形成后,各国研究室对此展开了大量的实验,证实了这些细胞具有高度自我更新和多向分化潜能,可促进造血细胞克隆形成,分化为成骨细胞、成软骨细胞、脂肪细胞甚至成肌细胞。直到1991年,Caphan把这些 Since Friendenstein discovered and confirmed the presence of an adherent, adherent spindle-shaped fibroblast colony in the bone marrow, a large number of experiments have been conducted in various countries to confirm that these cells have a high potential for self-renewal and multidirectional differentiation, Can promote hematopoietic cell clone formation, differentiation into osteoblasts, into chondrocytes, adipocytes and even myoblasts. Until 1991, Caphan took these