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传统三隔间肺模型的设想是:生理分流比值(■s/■t)保持恒定,而心输出量(■t)改变。结果,当■t减少时,动脉氧分压(Pao_2)与混合静脉氧分压(P■o_2)也必定减少。但对肺水肿的狗和患成人呼吸窘迫综合症(ARDS)的人类的观察表明:当■t减少时,■s/■t偶而下降,而Pao_2增加。目前的研究旨在用伴有扩散损伤的肺气交换计算机模型对这些不一致的观察结果进行检查。气体交换计算机模型专用于分析在扩散损伤情况下,■t的改变对Pao_2与■s/■t的影响。采用传统的三
The idea of a traditional three-compartment lung model is that the physiological shunt ratio (■ s / ■ t) remains constant while the cardiac output (■ t) changes. As a result, the partial pressure of arterial oxygen (Pao_2) and the partial pressure of mixed venous oxygen (P · o_2) also decreased as t decreased. However, observations in humans with pulmonary edema in dogs and adults with respiratory distress syndrome (ARDS) show that when t decreases, s / t decreases occasionally and Pao 2 increases. The current study aims to examine these inconsistent observations with a computer model of lung-gas exchange with diffusion lesions. The gas exchange computer model is designed to analyze the effect of the change of t on Pao_2 and s / t in the case of diffusion damage. Using the traditional three