论文部分内容阅读
对小诺霉素治疗的３０例患儿进行尿Ｎ－乙酰－β－Ｄ氨基葡萄糖胺酶（ＮＡＧ）的动态监测。小诺霉素用１周时尿ＮＡＧ较对照组明显增高（Ｐ＜０．０１），说明小诺霉素具有肾毒性作用，用药勿超过１周。尿ＮＡＧ是监测药物肾毒性的早期灵敏指标。
Urinary N-acetyl-β-D glucosaminidase (NAG) was monitored dynamically in 30 children treated with Trichoderma. Urinary NAG at 1 week was significantly higher than that of the control group (P <0.01), indicating that minocycline has renal toxicity and should not be administered for more than 1 week. Urinary NAG is an early and sensitive indicator of nephrotoxicity.