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目的：观察吸入一氧化氮（ＮＯ）治疗急性呼吸窘迫综合征（ＡＲＤＳ）时对其血流动力学和气体交换的影响。方法：选择８例ＡＲＤＳ患者，吸入０．００３％的ＮＯ，观察３个时相点：（１）基础值；（２）开始吸入ＮＯ后２０分钟；（３）停止吸入ＮＯ后２０分钟。结果：吸入ＮＯ使平均肺动脉压从（３．７３±０．６３）ｋＰａ（１ｋＰａ＝７．５ｍｍＨｇ）下降至（３．２０±０．５３）ｋＰａ（Ｐ＜０．０１），使肺血管阻力指数从（４０．６±６．３）ｋＰａｓＬ－１ｍ２下降至（３１．１±４．７）ｋＰａｓＬ－１ｍ２（Ｐ＜０．０１），而体循环指标无明显变化；与此同时，动脉血氧分压从（９．０７±２．２７）ｋＰａ上升至（１１．６０±２．８０）ｋＰａ（Ｐ＜０．０１），动脉血氧含量从（１２２±２１）ｍｌ／Ｌ上升至（１２８±２０）ｍｌ／Ｌ（Ｐ＜０．０１），动脉氧供应指数从（３８６±８９）ｍｌｍｉｎ－１ｍ－２增加至（４３７±９９）ｍｌｍｉｎ－１ｍ－２（Ｐ＜０．０１），而肺泡动脉氧分压差从（４１．３０±４．２７）ｋＰａ下降至（３８．５０±５．３３）ｋＰａ（Ｐ＜０．０１），肺内分流率从０．３４±０．０５下降至０．２９±０．０４（Ｐ＜０．０１）；停止吸入ＮＯ２０分钟后?
Objective: To observe the effects of inhaled nitric oxide (NO) on hemodynamics and gas exchange in the treatment of acute respiratory distress syndrome (ARDS). METHODS: Eight patients with ARDS were enrolled and 0.003% NO was inhaled. Three time points were observed: (1) basal values; (2) 20 minutes after inhalation of NO; and (3) 20 minutes after the inhalation of NO was stopped. Results: NO inhalation decreased mean pulmonary artery pressure from (3.73 ± 0.63) kPa (1kPa = 7.5mmHg) to (3.20 ± 0.53) kPa (P <0.01) Index decreased from (40.6 ± 6.3) kPasL-1m2 to (31.1 ± 4.7) kPasL-1m2 (P <0.01), while there was no significant change in body circulation index. Meanwhile, arterial oxygenation The partial pressure increased from (9.07 ± 2.27) kPa to (11.60 ± 2.80) kPa (P <0.01), and the arterial oxygen content increased from (122 ± 21) ml / L to Arterial oxygen supply index increased from (386 ± 89) mlmin-1m-2 to (437 ± 99) mlmin-1m-2 (P <0.01) The partial pressure of oxygen in alveolar artery decreased from (41.30 ± 4.27) kPa to (38.50 ± 5.33) kPa (P 0.01), intrapulmonary shunt fraction decreased from 0.34 ± 0.05 to 0.29 ± 0.04 (P <0.01); minutes after stopping the suction NO20?