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目的探讨合并不同血清高密度脂蛋白胆固醇(HDL-C)水平早发冠心病患者临床类型及冠状动脉病变的特点。方法入选100例因胸痛或胸闷不适行冠状动脉造影并确诊为早发冠心病的患者。以 HDL-C 水平分为两个亚组,并对冠脉病变程度进行分型,与100例非冠心病对照组进行比较分析。结果早发冠心病组血清HDL-C(1.07±0.27 mmol/L)明显低于对照组(1.16±0.26 mmol/L,P<0.05);早发冠心病患者中 HDL-C 低于0.9mmol/L 亚组中,临床表现为急性冠脉综合征的比例高(69.2%),且明显高于稳定型心绞痛组(23.9%,P<0.05)。冠状动脉为 C 型病变组 HDL-C 明显低于 A、B 型病变组(P<0.05)。结论早发冠心病患者血清 HDL-C 水平与临床类型及冠状动脉病变类型密切相关。
Objective To investigate the clinical characteristics and coronary artery lesions in patients with premature coronary heart disease (CHD) at different HDL-C levels. Methods 100 cases of patients with chest pain or chest tightness due to coronary angiography and diagnosed as premature coronary heart disease patients. The levels of HDL-C were divided into two subgroups, and the degree of coronary artery lesion was classified, and compared with 100 non-coronary heart disease control group. Results HDL-C (1.07 ± 0.27 mmol / L) in premature coronary heart disease group was significantly lower than that in control group (1.16 ± 0.26 mmol / L, P <0.05) In the L subgroup, the clinical presentation was high in patients with acute coronary syndrome (69.2%) and significantly higher than those in patients with stable angina (23.9%, P <0.05). HDL-C in C-type lesion group was significantly lower than that in A and B lesion group (P <0.05). Conclusion Serum HDL-C levels in patients with premature coronary heart disease are closely related to the clinical type and type of coronary artery lesions.