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目的：采用大样本随机双盲对照方法对国产和进口安氟醚临床应用进行比较。方法：心血管手术病人６０７例，随机分为国产安氟醚组（３０７例）和进口安氟醚组（３００例）。比较术后清醒时间、拔除气管插管时间、住ＩＣＵ和术后住院时间、术后心律失常发生率、术后神经系统并发症和肺部并发症的发生率以及术后死亡率。６０７例中随机抽出２０４例（国产组１０６例、进口组９８例）测定术后血清谷丙转氨酶（ＧＰＴ）、血清尿素氮（ＢＵＮ）和血清肌酐浓度（Ｃｒ）。随机抽出９７例（国产组５２例、进口组４５例）观察术后３天内有无恶心呕吐。结果：国产安氟醚与进口安氟醚比较仅心律失常发生率显著增高（２２１％比１４７％，Ｐ＜００５），其余各项无显著差异。结论：国产安氟醚基本上可与进口安氟醚一样应用于临床麻醉。
OBJECTIVE: To compare the clinical application of domestic and imported enflurane with a large sample randomized double-blind comparison. Methods: Sixty-seven patients with cardiovascular surgery were randomly divided into domestic enflurane group (307 cases) and imported enflurane group (300 cases). The postoperative recovery time, intubation time, ICU and postoperative hospital stay, incidence of postoperative arrhythmia, postoperative neurological complications and pulmonary complications and postoperative mortality were compared. The serum levels of GPT, serum BUN and serum creatinine (Cr) were measured in 204 cases (106 cases in domestic group and 98 cases in imported group) after 607 patients were randomly selected. 97 patients were randomly selected (domestic group of 52 cases, 45 cases of import group) to observe the postoperative 3 days with or without nausea and vomiting. Results: Compared with the imported enflurane, the incidence of arrhythmia was significantly higher (221% vs 147%, P <005), while the other items were not significantly different. Conclusion: Domestic enflurane basically can be applied to clinical anesthesia as imported enflurane.