论文部分内容阅读
本文对30例宫颈癌活检组织标本用直接法制备了染色体并进行了G显带，结果22例成功进行了核型分析。研究发现．21例鳞癌均无明显染色体人数，对Ⅱ期及Ⅲ期病例比较提示，非近二倍体细胞的增加与病期进展相关；各条正常染色体计数分析发现，20号、19号、8号及5号染色体明显高表达，而14号、22号、13号及15号染色体明显低在达；Ⅱ期与Ⅲ期病例比较提示，20号、8号染色体高表达及14号、22号染色体的低表达可能与宫颈癌的维持有关，而7号、3号和1号染色体的减少及19号染色体的表达增多可能与宫颈癌的发展相关。染色体结构畸变主要涉及1号、17号、11号和3号染色体，主要标记染色体有17p＋，11p＋，del（1）（p11），del（1）（p22）及3q异常等．这些标记梁卫体的出现可能与宫颈癌的发生发展相关。
In this paper, 30 cases of cervical cancer biopsy tissue samples prepared by direct chromosomal and G-banding, the results of 22 cases successfully karyotype analysis. The study found. 21 cases of squamous cell carcinoma had no obvious number of chromosomes, compared with the cases of stage Ⅱ and Ⅲ, the increase of non-diploid cells was related to the progress of the stage. The analysis of each chromosome showed that 20, 19, 8 And chromosome 5 were overexpressed, while chromosomes 14, 22, 13 and 15 were significantly lower than those in stage ¢ ó. A comparison between stage ¢ ó and ¢ ó showed that chromosomes 20 and 8 were highly expressed and chromosomes 14 and 22 May be related to the maintenance of cervical cancer. However, the decrease of chromosomes 7, 3 and 1 and the increase of chromosome 19 may be related to the development of cervical cancer. Chromosomal structural aberrations mainly involve the chromosomes 1, 17, 11 and 3, the main markers chromosome 17p +, 11p +, del (1) (p11), del (1) (p22) and 3q abnormalities. The appearance of these marks Liang Wei body may be related to the occurrence and development of cervical cancer.