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目的探讨维生素D受体(VDR)基因Apa I位点多态性与结直肠癌的关系。方法检索Medline、Pub Med、Embase和ISI Web of Science数据库,按照既定的纳入标准进行筛选后,采用Meta分析法研究VDR基因Apa I多态性与结直肠癌的关系,本次Meta分析分别采用显性、隐性、等位和相加模型对纳入数据进行分析。所有的分析都采用Stata 11.0软件处理。结果最终纳入9项研究,包括了9 173名受试者(4 396名结直肠癌患者和4 777名对照患者)。VDR基因Apa I多态性与结直肠癌风险相关性OR合并值在显性、隐性、等位和相加模型中分别为1.10(95%CI:0.88~1.39)、0.92(95%CI:0.78~1.09)、1.01(95%CI:0.88~1.15)和0.97(95%CI:0.73~1.28)。按照研究对象的种族、研究对照人群的来源以及Apa I基因频率是否符合HWE将所有纳入人群进行亚组Meta分析。结果显示,三种因素的亚组Meta分析均未发现Apa I多态性与结直肠癌之间存在显著的相关性。经Egger’s发表偏倚检验,本次Meta分析不存在显著的发表偏倚。结论 VDR基因Apa I多态性与结直肠癌之间没有显著相关性。
Objective To investigate the relationship between the Apa I polymorphism of vitamin D receptor (VDR) gene and colorectal cancer. Methods Medline, Pub Med, Embase and ISI Web of Science databases were searched and screened according to the established inclusion criteria. Meta-analysis was used to investigate the relationship between VDR gene Apa I polymorphism and colorectal cancer. Meta-analysis was performed using the significant Sex, Implicit, Allelic and Additive models were used to analyze the inclusion data. All analyzes are handled using Stata 11.0 software. The results eventually included 9 studies, including 9,173 subjects (4,396 colorectal cancer patients and 4,777 control patients). The odds ratio (OR) of VDR gene Apa I polymorphism and colorectal cancer risk was 1.10 (95% CI: 0.88-1.39), 0.92 (95% CI: 0.78 to 1.09), 1.01 (95% CI: 0.88 to 1.15) and 0.97 (95% CI: 0.73 to 1.28). According to the ethnicity of the study subjects, the source of the control population and whether the Apa I gene frequency was in line with HWE were included in all subgroups for meta-analysis. The results showed that there was no significant correlation between Apa I polymorphism and colorectal cancer in the three subgroup Meta analysis. According to Egger’s publication bias test, there is no significant publication bias in this meta-analysis. Conclusion There is no significant correlation between Apa I polymorphism of VDR gene and colorectal cancer.