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目的:紫龙金对鼻咽癌放射增敏作用临床研究,以及增敏机制的探讨。方法:临床研究随机将鼻咽癌分为两组,放射增敏组在放疗的同期给予口服紫龙金。治疗前及放疗20GY/10f时分别予鼻咽部病理活检,行P16和cyclinD1免疫组化。结果:研究表明紫龙金癌在鼻咽癌放疗增敏效果显著,增敏组放疗结束时CR率远远高于对照组,但两组的2年生存率、2年无复发生存率、2年无远处转移生存率无统计学上显著差异。与对照组相比,增敏组P16有上调趋势、cyclinD1有下调趋势,但无统计学差异。结论:近期疗效表明紫龙金对鼻咽癌有放射增敏作用,需进一步随访对远期生存率进行疗效评价。增敏作用机制可能是通过P16上调和cyclinD1下调。
OBJECTIVE: To investigate the radiosensitization effect of Zilongjin on nasopharyngeal carcinoma and its mechanism of sensitization. Methods: The clinical study randomized nasopharyngeal carcinoma into two groups. The radiation-sensitized group received oral Zi Longjin during the same period of radiotherapy. Before treatment and radiotherapy 20GY / 10f were nasopharyngeal biopsy, line P16 and cyclinD1 immunohistochemistry. Results: The results showed that Zilongjin cancer had significant sensitizing effect on radiotherapy of nasopharyngeal carcinoma. The CR rate in the sensitized group was much higher than that of the control group at the end of radiotherapy. However, the 2-year survival rate and 2-year non-recurrence survival rate were significantly different between the two groups There was no statistically significant difference in distant metastasis years without metastasis. Compared with the control group, sensitized group P16 up-trend, cyclinD1 down trend, but no significant difference. Conclusion: The recent curative effect shows that Zilongjin radiosensitises nasopharyngeal carcinoma and needs further follow-up to evaluate the curative effect of long-term survival. Sensitization mechanism may be through the P16 and cyclinD1 down regulation.