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本文研究了同系和异种动物再生肝胞浆液对大鼠急性实验性肝衰的疗效,并初步探讨了作用机理,用10%氨基半乳糖腹腔注射引起大鼠暴发性肝功能衰竭、实验结果表明,与对照组和成年大鼠正常肝胞浆液治疗组比较,同系和异种动物(狗)再生肝胞浆液治疗组有显著提高病鼠的存活率的作用(P<0.01),~3H-胸苷参入的实验证明狗再生肝胞浆液治疗组肝DNA合成率为对照组的2.5倍,提示促进病损肝脏再生是其发挥治疗作用的重要机制,狗再生肝胞浆液治疗组于治疗后24小时及48小时,血清BSP潴留量和总胆红素浓度均显著低于对照组(P<0.05)。
This article studied the effect of syngeneic and xenogeneic regenerative hepatic cytoplasm on experimental acute hepatic failure in rats and preliminary explored the mechanism of action. Intraperitoneal injection of 10% aminogalactose caused fulminant hepatic failure in rats. Experimental results show that Compared with the normal hepatic serous fluid treatment group in the control and adult rats, the syngeneic and xenogeneic (dog) regenerating hepatic cytoplasmic fluid treatment group significantly improved the survival rate of the diseased mice (P<0.01), ~3H- The experiment of thymidine incorporation showed that the hepatic DNA synthesis rate of the dog regenerating liver cytoplasmic solution treatment group was 2.5 times that of the control group, suggesting that the promotion of lesion liver regeneration is an important mechanism for its therapeutic effect, and the dog regenerative liver cytoplasmic treatment group was treated After 24 hours and 48 hours, serum BSP retention and total bilirubin concentrations were significantly lower than those in the control group (P<0.05).