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母体对胎儿血小板产生同种抗体或患自身免疫性血小板减少症者均可导致其所生婴儿患新生儿血小板减少症。临床上为给血小板减少的婴儿施以有效的输血治疗,需要对这两种原因引起的疾病加以鉴别。因此,作者前瞻性地对被Pl~(Al)抗原致敏且于近期分娩患同种免疫性血小板减少症婴儿的母亲进行检测,以期证实妊娠期间母体对胎儿Pl~(Al)抗原发生免疫后是否出现血小板相关免疫球蛋白(PA IgG)升高。采用~(125)I 标记的亲合纯羊抗人IgG测定PAIgG,结果表明,19例被检者中8例在第一次妊娠中PAIgG升高(平均2.9±0.6,1SD),且持续到分娩后第7～10夭。对照组25例孕妇分娩后1～2日内
Maternal production of alloantibodies to fetal platelets or autoimmune thrombocytopenia may result in neonatal thrombocytopenia in infants born to the same. Clinically, providing effective blood transfusions to thrombocytopenic infants requires identification of these two causes of disease. Therefore, the authors prospectively tested the mothers who were sensitized with Pl ~ (Al) antigen and had the most recent delivery of alloimmune thrombocytopenia in order to confirm the maternal immunity to the fetus’s P1 ~ (A1) antigen during pregnancy Whether there is platelet-associated immunoglobulin (PA IgG) increased. The results of PAIgG assay using ~ (125) I labeled affinity goat anti-human IgG showed that PAIgG was elevated in the first trimester (mean 2.9 ± 0.6, 1SD) in 8 of 19 subjects 7 to 10 days after childbirth. Control group, 25 cases of pregnant women within 1 to 2 days after delivery