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目的探讨老年患者医院感染与甲状腺功能变化之间的联系,总结临床经验,为甲状腺功能病态综合征(ESS)的预防治疗工作提供理论依据。方法选择医院2012年12月-2013年12月收治的408例患有慢性疾病且无甲状腺疾病的老年患者作为研究对象,调查患者医院感染前后甲状腺功能变化,对患者高敏C-反应蛋白(hsCRP)、甲状腺功能、血清白蛋白和血白细胞等指标进行感染前后的对比,分析其变化趋势,所有数据采用SPSS18.0软件进行分析。结果 408例患有慢性疾病且无甲状腺疾病的老年患者有28例发生医院感染,医院感染率为6.9%;发生医院感染前患者出现ESS的概率为89.3%,发生医院感染后,全部患者均出现ESS,ESS发生率为100.0%;患者发生医院感染后甲状腺功能TT3、TT4、FT3等指标较感染前有明显下降,数据分析比较差异有统计学意义(P<0.05),感染后所有患者均未出现游离T4降低。结论控制医院感染的发生对于老年患者甲状腺功能病态综合征的防治具有较高的临床意义。
Objective To explore the relationship between nosocomial infection and thyroid function in senile patients and to summarize the clinical experience to provide a theoretical basis for the prevention and treatment of thyroid function sick syndrome (ESS). Methods A total of 408 elderly patients with chronic diseases without thyroid disease admitted from December 2012 to December 2013 in our hospital were enrolled in this study. Thyroid function was examined before and after nosocomial infection in patients. HsCRP, , Thyroid function, serum albumin and white blood cells and other indicators of infection before and after comparison, analysis of its trends, all data using SPSS18.0 software for analysis. Results In 408 elderly patients with chronic diseases and without thyroid disease, nosocomial infections occurred in 28 patients and the nosocomial infection rate was 6.9%. The incidence of ESS before nosocomial infection was 89.3%. After nosocomial infection, all of the patients appeared The incidence of ESS and ESS was 100.0%. Thyroid function TT3, TT4 and FT3 in patients with nosocomial infection were significantly lower than those before infection (P <0.05), and no significant difference was found in all the patients after infection Free T4 decreased. Conclusion Controlling the occurrence of nosocomial infection has a high clinical significance for the prevention and treatment of thyroid functional sick syndrome in elderly patients.