应用免疫组织化学（ＳＰ）方法研究了１４例正常前列腺、５６例前列腺增生和３３例前列腺癌组织中表皮生长因子受体（ＥＧＦＲ）的表达。结果显示，ＥＧＦＲ分布于上皮细胞；前列腺癌和增生组织中ＥＧＦＲ阳性率分别为９３９％和８７５％，均明显高于正常前列腺５７１％；ＥＧＦＲ表达与癌细胞分化程度有关，各病理分期中ＥＧＦＲ表达也有差别。提示ＥＧＦＲ与前列腺增生及癌变的发生有关，可作前列腺癌生物学行为的判断指标。 Immunohistochemistry (SP) was used to study the expression of epidermal growth factor receptor (EGFR) in 14 cases of normal prostate, 56 cases of benign prostatic hyperplasia and 33 cases of prostate cancer. The results showed that EGFR was distributed in epithelial cells. The positive rates of EGFR in prostate cancer and hyperplastic tissues were 939% and 875%, respectively, which were significantly higher than those in normal prostate (571%). EGFR expression was related to the degree of cancer cell differentiation, EGFR expression in each pathological stage is also different. Tip EGFR and benign prostatic hyperplasia and cancer related to the biological behavior of prostate cancer can be used as a judge.