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目的 分析总结18 F-FDG PET/CT在儿童及青少年淋巴母细胞淋巴瘤/白血病(LL/ALL)中的影像学表现及其分期价值.方法 回顾性分析15例LL/ALL初诊患儿(男9例,女6例,年龄1 ～ 20岁)的临床资料及18F-FDG PET/CT图像,采用两样本t检验、Mann-Whitneyu检验及x2检验比较不同表型LL/ALL的临床参数、SUVmax及T/B比值,分析计算PET/CT诊断骨髓肿瘤浸润的灵敏度、特异性及准确性.结果 15例LL/ALL患儿中,T细胞表型(T-LL/ALL)9例,B细胞表型(B-LL/ALL)6例.T-LL/ALL的中位SUVmax为9.4(3.9～ 14.3),B-LL/ALL的中位SUVmax为5.7(2.3～8.6),2种表型淋巴瘤的18F-FDG代谢差异无统计学意义(u=14.000,P＞0.05).结合骨髓活组织检查及影像学表现,9例患儿被确诊淋巴瘤骨髓浸润.将骨髓多灶性FDG浓聚和(或)弥漫性代谢增高作为PET诊断骨髓肿瘤累及的标准,则PET/CT的灵敏度、特异性及准确性分别为8/9、4/6及12/15;若仅将骨髓多灶性FDG浓聚作为诊断标准,则相应指标分别为5/9、6/6及11/15;BMB的相应指标分别为5/9、6/6及11/15.结论 18F-FDG PET/CT在不同表型LL/ALL患儿中的影像学表现具有一定特点,与BMB相结合有助于患儿危险分层.“,”Objective To explore the imaging features and staging lymphoblastic lymphoma/acute lymphoblastic leukemia (LL/ALL) on 18F-FDG PET/CT in children and adolescents.Methods Fifteen consecutive children and adolescents with newly diagnosed LL/ALL (9 males,6 females,age range:1-20 years) were included in this retrospective study.Clinic-pathological variables and 18F-FDG PET/CT scans were reviewed.Clinical parameters,SUVmax and T/B ratios of patients with different phenotype LL/ALL were compared using Mann-Whitney u test.The sensitivity,specificity and accuracy of 18F-FDG PET/CT to diagnose bone marrow involvement (BMI) were calculated.Results Nine patients were T-LL/ALL,6 were B-LL/ALL.The median SUVmax of T-LL/ALL was 9.4 (3.9-14.3),and that of B-LL/ALL was 5.7 (2.3-8.6).No significant difference of SUVmax was observed (u =14.000,P＞0.05).Nine patients were identified to have bone marrow involvement.If multifocal FDG accumulation and diffuse hypermetabolism in bone marrow were considered as BMI,the sensitivity,specificity and accuracy for PET/CT to identify BMI was 8/9,4/6 and 12/15,respectively.If only multifocal FDG accumulation in bone marrow was considered as BMI,the parameters of PET/CT were 5/9,6/6 and 11/15,respectively.For BMB,the parameters were 5/9,6/ 6 and 11/15,respectively.Conclusion 18F-FDG PET/CT could help to identify LL/ALL with BMI,especially in patients with a negative BMB.