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目的 :探讨乙胺碘呋酮对Q -TC 间期的早期影响及意义。方法 :按每公斤体重 15mg单次服用乙胺碘呋酮 ,然后对患者进行 72h血药浓度及心电图Q -TC 间期监测。结果 :血药浓度与Q -TC 间期延长及抗心律失常疗效呈正相关 ,相关系数分别是 0 .70及 0 .74。Q -TC 间期延长与抗心律失常疗效的相关性更好 ,相关系数为 0 .99。Q -TC 间期较用药前平均延长了 (13 .8± 3 .9) % ,疗效明显 ,无与此有关的心律失常发生。结论 :服用乙胺碘呋酮时Q -TC 间期的延长是一定血药浓度及发挥疗效的标志 ,Q -TC 间期延长 2 5 %可能仍属安全范围。
Objective: To investigate the early effect of amiodarone on Q -TC interval and its significance. Methods: A total of 15 mg / kg body weight of amiodarone was taken, and then the patient was monitored for plasma 72h plasma concentration and Q-TC interval. Results: The plasma concentrations were positively correlated with the prolongation of Q-TC interval and the antiarrhythmic effect, with correlation coefficients of 0.70 and 0.74, respectively. The correlation between Q-TC prolongation and antiarrhythmic efficacy was better with a correlation coefficient of 0.99. Q -TC interval longer than the average before treatment (13.8 ± 3.9)%, significant effect, no arrhythmia associated with this. CONCLUSION: The prolongation of Q -TC interval when taking amiodarone is a sign of certain blood concentration and curative effect. The prolongation of 25% of Q-TC interval may still be safe.