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银屑病是一种慢性炎症性皮肤病。它不仅累及患者的皮肤、黏膜,还经常侵犯患者的骨及关节,病程缓慢,容易复发。中重度银屑病患者的治疗非常顽固性和个体差异性。银屑病的系统治疗往往有很强的依赖性,停药后容易复发。生物制剂的临床应用对银屑病治疗提供了一种有效手段。然而值得强调的是,抗肿瘤坏死因子的临床应用可能会导致潜伏结核的复发,扩散。医生在给患者使用生物制剂治疗前,应给患者作必要的检测,排除潜在结核感染的存在。但是在临床应用的各种结核检测方法都不能完全有效的筛查结核感染的存在。
Psoriasis is a chronic inflammatory skin disease. It not only affects the patient’s skin, mucous membranes, but also often invades the patient’s bones and joints, slow course, easy to relapse. The treatment of patients with severe psoriasis is very stubborn and individual differences. Systemic treatment of psoriasis often has a strong dependence, easy to relapse after stopping. The clinical application of biological agents for psoriasis treatment provides an effective means. However, it is worth emphasizing that the clinical application of anti-tumor necrosis factor may lead to the recurrence and spread of latent tuberculosis. The doctor should give the patient the necessary tests to rule out the presence of a potential TB infection before treating the patient with a biologic agent. However, none of the various tuberculosis detection methods used in clinical application can completely and effectively screen for the presence of tuberculosis infection.