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目的:了解一氧化氮(nitric oxide,NO)在急性内毒素血症肝损害发病中的作用。方法:采用内毒素(脂多糖,LPS)腹腔内注射,观察大鼠血清NO产物、ALT、AST及LDH水平变化和肝组织结构改变情况。结果:LPS给药后,大鼠血清NO产物、ALT、AST及LDH水平均呈LPS剂量依赖型升高,肝组织结构明显改变,并且NO产物水平与ALT、AST及LDH水平和肝组织病变程度平均积分均呈正相关。结论:在急性内毒素血症肝损害发病中,NO可能具有重要作用,并且血清NO产物水平可以作为该肝损害发生的早期观察指标之一。
Objective: To understand the role of nitric oxide (NO) in the pathogenesis of acute liver injury induced by endotoxemia. Methods: Endotoxin (LPS) was injected intraperitoneally to observe the changes of serum NO, ALT, AST and LDH levels and the changes of hepatic tissue structure in rats. Results: After LPS administration, the levels of NO, ALT, AST and LDH in rat serum all increased in a dose-dependent manner in LPS group. The changes of NO production, ALT, AST and LDH levels, The average points were positively correlated. CONCLUSION: NO may play an important role in the pathogenesis of liver injury induced by acute endotoxemia, and serum NO production level may serve as one of the early observation indicators of liver damage.