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利用电化学阻抗谱原位监测浸泡在人体模拟液(SBF)中生物活性PEO陶瓷膜表面上羟基磷灰石(HA)的形核和生长过程,评价PEO陶瓷膜的体外生物活性.结果表明,在SBF模拟液中浸泡7 d后,含硅PEO陶瓷膜阻抗谱的高频段出现一个新的时间常数;同时,最外层氧化膜电阻值显著增加,说明HA晶粒在膜层表面形核并快速生长;基准PEO陶瓷膜在SBF模拟液中浸泡18 d后,最外层电阻值才有上升趋势,而且增长速度非常缓慢.含硅PEO陶瓷膜中CaSiO3和SiO2为羟基磷灰石的沉积提供了更多的异质形核点,因此大大提高其生物活性.
The electrochemical impedance spectroscopy was used to monitor the nucleation and growth of hydroxyapatite (HA) on the surface of bioactive PEO ceramic membrane immersed in human simulated fluid (SBF) in situ, and the bioactivity of PEO ceramic membrane was evaluated. After soaking for 7 d in SBF simulation liquid, a new time constant appeared in the high frequency band of the impedance spectrum of silicon-containing PEO ceramic membrane. At the same time, the resistance value of the outermost oxide film increased significantly, indicating that the HA grains were nucleated on the surface of the film Fast growth.The resistance of the outermost layer of PEO ceramic membrane increased only after soaking for 18 d in the SBF simulation liquid and the growth rate was very slow.The deposition of CaSiO3 and SiO2 in the PEO ceramic membrane containing hydroxyapatite More heterogeneous nucleation sites, thus greatly increasing their biological activity.