Yajima T等进行了临床实验以评价西地那非对健康男性志愿者眼内压的短期作用。在两个安慰剂对照研究中,他们分别测量了眼内压和瞳孔直径,给受试者口服西地那非的剂量范围为10mg～150mg。结果显示,服用西地那非后的1h～24h之间眼内压及瞳孔测量值无较大变化。此外,在西地那非安全性数据库中包括的36位既往有过眼压增高史的患者在本次实验中眼压亦无临床有意义的增高。在临床实验中有两例青光眼患者发生了严重的不良事件,但研究认为与西地那非治疗无关。实验结论表明,患者使用西地那非后未见 Yajima T et al conducted clinical trials to evaluate the short-term effects of sildenafil on intraocular pressure in healthy male volunteers. In two placebo-controlled studies, they measured intraocular pressure and pupil diameter, respectively, and doses of sildenafil to subjects ranged from 10 mg to 150 mg. The results showed that after taking sildenafil between 1h ~ 24h intraocular pressure and pupil measurements did not change significantly. In addition, 36 patients with previous history of elevated intraocular pressure included in the sildenafil safety database also had no clinically significant increases in intraocular pressure during this study. Two serious glaucoma patients experienced serious adverse events in clinical trials, but the study concluded that treatment with sildenafil had no effect. Experimental results show that patients with sildenafil after no