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采用经胸动态三维超声心动图（３Ｄ－Ｅｃｈｏ）对１５例二尖瓣狭窄（ＭＳ）患者的二尖瓣口面积（ＭＶＡ）进行了定量研究。通过心脏三维重建仪平行切割二尖瓣结构衍生出８个从二尖瓣环至瓣尖的等距离短轴平面，从中能够确定并测量代表最小ＭＶＡ的平面。结果显示３Ｄ－Ｅｃｈｏ测量的ＭＶＡ与多普勒压力半降时间（ＰＨＴ）导出的ＭＶＡ高度相关（ｒ＝０．９７，Ｐ＜０．００１），经胸二维超声心动图（２Ｄ－Ｅｃｈｏ）测量的ＭＶＡ与３Ｄ－Ｅｃｈｏ测量的ＭＶＡ仅中度关连（ｒ＝０．８３，Ｐ＜０．０１），２Ｄ－Ｅｃｈｏ测量的ＭＶＡ平均大于３Ｄ－Ｅｃｈｏ测量的ＭＶＡ为０．３８ｃｍ２，这可能与从胸骨旁短轴切面上难以切扫到最小的瓣口平面有关。本研究表明３Ｄ－Ｅｃｈｏ为定量评价ＭＳ患者的ＭＶＡ提供了一种更准确的全新影像技术。
Mitral orifice area (MVA) was quantified in 15 patients with mitral stenosis (MS) using transthoracic dynamic three-dimensional echocardiography (3D-Echo). Parallel cutting of the mitral valve structures by a three-dimensional reconstruction of the heart derives eight equidistant minor axis planes from the mitral annulus to the cusp, from which the plane representing the smallest MVA can be determined and measured. The results showed that MVA measured by 3D-Echo was highly correlated with MVA derived from Doppler pressure drop-off time (PHT) (r = 0.97, P <0.001), transthoracic two-dimensional echocardiography MVA measured was moderately correlated with MVA measured by 3D-Echo (r = 0.83, P <0.01), MVA averaged by 2D-Echo was greater than MVA measured by 3D-Echo was 0.38 cm2, It is difficult to cut from the parasternal short axis view to the smallest flap plane. This study shows that 3D-Echo provides a more accurate new imaging technique for quantitative assessment of MVA in MS patients.