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目的 :观察精制蛇毒复方胶囊治疗胃癌术后患者的临床疗效。方法 :60例病例随机分两组。治疗组 30例 ,口服精制蛇毒复方胶囊 ,每次 4粒 ,每日 3次。对照组 30例 ,辨证施治 ,口服中药汤剂。疗程为 2个月。治疗前后观察 :临床症状、生存质量、血液流变学指标、免疫指标、生存期及复发转移率。结果 :治疗组与对照组均能改善患者脘腹疼痛、腹胀等症状 (P<0 .0 5 ) ;两组均能提高患者生存质量 (P<0 .0 5 ) :治疗组能明显降低患者高纤维蛋白原和高血浆粘度 (分别为 P<0 .0 1、P<0 .0 5 ) ,而对照组无明显降低作用 (P>0 .0 5 ) ,治疗后两组之间比较存在明显差异 (上述两指标分别为 P<0 .0 1、P<0 .0 5 ) ;治疗组平均生存期 32 .7月 ,对照组 2 5 .2月 ,两组有明显差异 (P<0 .0 5 ) ;生存率治疗组高于对照组 ,分别为 76.7%和 60 % (P<0 .0 5 ) ;治疗组复发转移 8例 (2 6.7% ) ,对照组 13例 (4 3.3% ) ,治疗组复发转移率低于对照组 (P<0 .0 5 ) ;两组治疗前后 T细胞亚群和 NK细胞指标均无明显变化。结论 :精制蛇毒复方胶囊对改善胃癌术后患者临床症状、提高生存质量、改善高粘血症、延长生存期、延缓肿瘤复发转移具有一定的疗效 ,值得进一步研究和应用。
Objective: To observe the clinical efficacy of the refined snake venom compound capsule in the treatment of postoperative patients with gastric cancer. Methods: Sixty cases were randomly divided into two groups. Treatment group 30 cases, oral purified snake venom compound capsules, each 4, 3 times a day. Control group of 30 cases, syndrome differentiation, oral medicine decoction. Treatment for 2 months. Before and after treatment: clinical symptoms, quality of life, hemorheology, immune parameters, survival and recurrence and metastasis rate. Results: Both the treatment group and the control group could improve the symptoms such as abdominal pain and abdominal distension (P <0.05), and both groups could improve the quality of life (P <0.05): the treatment group could significantly reduce the patients High fibrinogen and high plasma viscosity (P <0.01, P <0.05, respectively), while there was no significant decrease in the control group (P> 0.05). After treatment, there was a significant difference between the two groups (P <0.01, P <0.05). The mean survival time in the treatment group was 32.7 months, and in the control group was 25.2 months, there was a significant difference between the two groups (P <0. 01) (P <0.05). The survival rate in the treatment group was higher than that in the control group (76.7% vs 60%, P <0.05) ), The recurrence and metastasis rate in the treatment group was lower than that in the control group (P <0.05). There was no significant change in the T cell subsets and NK cells in both groups before and after treatment. Conclusion: The purified compound snake venom capsule has certain curative effect on improving clinical symptoms, improving quality of life, improving hyperviscosity, prolonging survival period and delaying the recurrence and metastasis of gastric cancer patients. It deserves further study and application.