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近年来,冠状动脉造影术、冠状动脉旁路术已证实急性透壁性心肌梗塞早期约80％冠状动脉内有血栓形成。大量研究资料表明:溶栓疗法在挽救频死心梗、缩小梗塞面积、改善左室功能以及降低急性心肌梗塞病死率等方面均有显著疗效。 一、溶栓药物及其作用机理 (一)链激酶(Streptokinase SK) SK与一分子纤溶酶原结合成复合体后再将游离的纤溶酶原转变成纤溶酶,故能促进新形成的血栓溶解。SK具有弱抗原性,对近期内有链球菌感染者可产
In recent years, coronary angiography, coronary artery bypass surgery has confirmed early acute transmural myocardial infarction in about 80% of coronary artery thrombosis. A large number of research data show that: thrombolytic therapy in the rescue of frequently-occurring myocardial infarction, reduce infarct size, improve left ventricular function and reduce mortality in acute myocardial infarction and other aspects have a significant effect. First, the thrombolytic drugs and its mechanism of action (a) Streptokinase SK SK and a molecule of plasminogen into a complex and then the free plasminogen into plasmin, it can promote the new formation Thrombolytic. SK has a weak antigenicity, can produce streptococcal infection in the near future