原发性中枢神经系统淋巴瘤(primary central nervous system lymphoma,PCNSL)是指患者诊断时肿瘤局限于大脑、小脑、脑干、眼、软脑膜和脊髓等中枢神经系统(CNS)部位,尚未发现累及CNS以外部位的淋巴瘤。PCNSL是非霍奇金淋巴瘤(non-Hodgkin’s lymphoma,NHL)的一个罕见类型,主要为B细胞起源,其发病机制尚未明确。PCNSL临床表现取决于淋巴瘤发生于CNS的部位, Primary central nervous system lymphoma (PCNSL) refers to the patient at the diagnosis of tumor confined to the brain, cerebellum, brainstem, eye, pia mater and spinal cord and other central nervous system (CNS) site, has not been found involved Lymphoma outside the CNS. PCNSL is a rare type of non-Hodgkin’s lymphoma (NHL), mainly the origin of B cells, the pathogenesis of which is unclear. The clinical manifestations of PCNSL depend on where lymphoma occurs in the CNS,