论文部分内容阅读
家兔10只，均分为两组，分别静脉及肌肉注射谱氟沙星注射液10mg／kg，用HPLC测得经时血药浓度。结果显示其两种给药途径的药时曲线均符合二定模型．其主要药动学参数静脉注射组为：C0（13．90±3．43）μg／ml，1/2：α（0.11±0．04）h．t1/2β（2．45±0．64）h，Vd（1．29±0．32）L/kg，AUC（10．39±2．60）mg·h／L，CL（2．01±3．47）L／kg·h；肌肉注射组为；Cmax（2．69±0．63）μg／ml，Tmasx（016±0．12）h，t1/2：Ka（0．02±0.03）h，t1/2α（0．53±0．56）h，t1/2β（2．83±0．47）h，Vd（7．60±1．63）L/kg，AUC（9．46±1．47）mg·h／L，CL（2．14±0．34）L／kg·h．F91％．
Rabbits 10, were divided into two groups, intravenous and intramuscular injection of fluocinacin injection 10mg / kg, measured by HPLC serum concentration over time. The results show that the two routes of administration of drug-time curve are consistent with two fixed model. The main pharmacokinetic parameters of intravenous injection group: C0 (13.90 ± 3.43) μg / ml, 1/2: α (0.11 ± 0.04) h. (2.14 ± 0.64) h, Vd (1.29 ± 0.32) L / kg, AUC (10.39 ± 2.60) mg · h / 3.47) L / kg · h; Cmax (2.69 ± 0.63) μg / ml, Tmasx (016 ± 0.12) h, t1 / 2: Ka ), T1 / 2α (0.53 ± 0.56) h, t1 / 2β (2.83 ± 0.47) h, Vd (7.60 ± 1.63) L / kg, AUC ± 1.47) mg · h / L, CL (2.14 ± 0.34) L / kg · h. F91%.