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目的探讨福州地区人乳头瘤病毒(HPV)感染的分子流行病学特点,从而为尖锐湿疣(CA)患者的监测提供一定的临床依据。方法采用HybriMax技术对福州地区600例CA患者的皮损组织进行HPV检测及分型。结果 585例患者呈HPV感染阳性,共发现20种HPV亚型。HPV单一型感染372例,占63.59%。213例存在2~6种亚型的混合感染,多重型别感染率达到36.41%(213/585)。结论福州地区尖锐湿疣患者以低危型HPV6/11为主,高危型HPV感染率高并多以混合感染形式存在。
Objective To explore the molecular epidemiological characteristics of human papillomavirus (HPV) infection in Fuzhou, so as to provide some clinical evidences for the monitoring of patients with condyloma acuminatum (CA). Methods The HybriMax technique was used to detect and classify the skin lesions in 600 CA patients in Fuzhou. Results 585 patients were HPV-positive, a total of 20 HPV subtypes were found. 372 cases of HPV infection of a single type, accounting for 63.59%. In 213 cases, there were 2 to 6 subtypes of mixed infection, the multiple type infection rate reached 36.41% (213/585). Conclusions The patients with genital warts in Fuzhou area are mainly low-risk HPV type 6/11. The high-risk type HPV infection rates are high and are mostly found in mixed infection.