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地方克汀病是世界上分布广泛、危害严重的地方病之一。至今,其病因和发病机制仍不十分清楚。根据大量流行病学和临床研究的资料,多数学者认为地方克汀病是由于胚胎期与新生儿期缺碘和甲状腺激素不足,造成中枢神经系统和骨骼系统等的不可逆性损伤所致。但在实验动物中,仅用单纯缺碘的方法,仍未能成功地复制出地方克汀病模型。本实验自妊娠中期直至哺乳期给母鼠饲以人工配制的低碘饮食,使仔鼠胚胎后期及哺乳期缺碘,采用运动防御条件反射,脑电图和脑的形态改变为指标,检查仔鼠脑功能和形态的变化,来探讨胚胎期和新生儿期缺碘在地方克汀病发病机制中的作用。本实验还以同样的方法检查了成年大鼠的脑功能和形态变化,观察成年期
Local cretinism is one of the most endemic and widespread endemic diseases in the world. So far, its etiology and pathogenesis is still not very clear. According to a large number of epidemiological and clinical research data, most scholars believe that local cretinism is due to lack of iodine and thyroid hormone in embryonic and neonatal period, resulting in irreversible damage to the central nervous system and skeletal system. However, in experimental animals, the local cretinism model has not been successfully replicated simply by iodine deficiency alone. This experiment from the second trimester until lactation to the mother rats fed artificial low-iodine diet, the pups late embryo and lactation iodine deficiency, exercise defensive reflex, EEG and brain morphological changes as an indicator of Aberdeen Mouse brain function and morphological changes to explore the role of iodine deficiency in the pathogenesis of local cretinism in embryonic and neonatal period. In this experiment, the same method was used to examine the changes of brain function and morphology in adult rats.