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目的对疑为新生儿溶血病患者,采集血样,进行直接抗人球蛋白试验、红细胞抗体释放试验、血清中游离抗体试验。探讨ABO血型不合引起新生儿溶血病的血型分布规律,为临床提供ABOHDN的诊断依据。方法应用微柱凝胶法2010年8月至2012年10月可疑为新生儿溶血病患者血样进行溶血三项试验,同时鉴定患儿及其母亲血型,参考患儿父亲血型,对检验结果进行分析。结果放散试验结果总阳性率23.52%,其中ABO血型系统中A型72例,阳性率41.66%。B型98例,阳性率10.20%。AB型8例,阳性率0%。Rh血型系统母亲为Rh阴性,患儿为Rh阳性者未检出阳性患儿。结论直接抗人球蛋白试验阳性率低于其他文献报道,A型和B型红细胞抗体释放试验阳性率有不大的差异。结合其他实验室检查,为临床提供早期诊断依据。
OBJECTIVE To collect blood samples from patients suspected of having hemolytic disease of newborn with direct anti-human globulin test, erythrocyte antibody release test and serum free antibody test. To investigate the blood type distribution of neonates with hemolytic disease caused by ABO blood group incompatibility and to provide diagnostic basis for clinical diagnosis of ABOHDN. Methods The microcolumn gel method from August 2010 to October 2012 suspected hemolytic disease in patients with hemolytic three tests, while identifying children and their mothers blood type, with reference to the father’s blood type, the test results were analyzed . Results The total positive rate of dissection test was 23.52%, of which 72 cases were type A in ABO blood group, the positive rate was 41.66%. 98 cases of type B, the positive rate of 10.20%. AB type in 8 cases, the positive rate of 0%. Rh blood group mother Rh-negative, Rh-positive children were not detected positive. Conclusions The positive rate of direct anti-human globulin test is lower than that reported in other literatures. The positive rates of A and B erythrocyte antibody release test are not significantly different. Combined with other laboratory tests for the clinical diagnosis to provide early basis.