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为探讨Ｈｕ抗体在神经系统副肿瘤综合征（ＰＮＳＮＳ）发病中的作用。用亲合免疫细胞组织化学ＡＢＣ法及免疫印迹技术测定１７例患者血清、脑脊液及尿液中的Ｈｕ抗体。结果显示１７例患者血清中Ｈｕ抗体滴度为１∶１０００至１∶６４０００；脑脊液（１５例）中滴度为１∶１０～１∶４０００；尿液（５例）中滴度为１∶２０～１∶２００。Ｈｕ抗体识别的抗原分子量为３５～４０万。提示Ｈｕ抗体是与ＰＮＳＮＳ有关的一种高度特异性自身抗体，ＰＮＳＮＳ可能为一种自身免疫性疾病，Ｈｕ抗体在致病过程中起重要作用。
To investigate the role of Hu antibody in the pathogenesis of paraneoplastic neuropathic syndrome (PNSNS). Immunohistochemical ABC method and immunoblotting were used to detect Hu antibody in serum, cerebrospinal fluid and urine of 17 patients. The results showed that the titer of Hu antibody in serum of 17 patients was 1:1000 to 1:64000; the titer of CSF in CSF was 1:10 to 1: 4000; the titer of urine in 5 patients was 1:20 ~ 1: 200. Hu antibody recognition antigen molecular weight of 35 to 400000. It is suggested that Hu antibody is a highly specific autoantibody associated with PNSNS, PNSNS may be an autoimmune disease and Hu antibody plays an important role in pathogenicity.