转录因子Yin Yang(YY)1在多种组织中广泛表达,YY1通过影响细胞增殖、凋亡及分化等生命过程,从而在生物体内发挥着重要作用。YY1具有复杂的转录调控机制,依赖于接触不同的蛋白辅助因子,可激活或抑制相关基因。已有大量有关YY1在各种肿瘤,如淋巴瘤、白血病、前列腺癌、乳腺癌、宫颈癌、结肠癌等中表达及调控机制的研究,结果表明YY1在绝大多数肿瘤中异常高表达,并且与其肿瘤的形成、进展及不良预后有关。本文从YY1的基因结构及调控机制入手,集中阐述YY1与血液肿瘤相关的研究进展,对其在常见血液肿瘤中的表达、功能及预后等关系等作一综述。 The transcription factor Yin Yang (YY) 1 is widely expressed in many tissues. YY1 plays an important role in the organism by affecting the process of cell proliferation, apoptosis and differentiation. YY1 has a complex transcriptional regulatory mechanism that relies on different protein cofactors, activating or repressing related genes. A large number of studies on the expression and regulation mechanism of YY1 in various tumors such as lymphoma, leukemia, prostate cancer, breast cancer, cervical cancer, colon cancer and the like have shown that YY1 is highly expressed in the vast majority of tumors, and With the formation of the tumor, progress and poor prognosis. This article starts with the gene structure and regulation mechanism of YY1 and focuses on the research progress of YY1 in hematological tumors and its relationship with the expression, function and prognosis of hematological malignancies.