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本文报道口服大剂量泼尼松治疗小儿特发性血小板减少性紫癜（ＩＴＰ）２９例，随机分为试验组１５例，对照组１４例．试验组每日泼尼松８ｍｇ／ｋｇ，每隔２日，剂量分别减至每日６ｍｇ／ｋｇ、４ｍｇ／ｋｇ、２ｍｇ／ｋｇ，共服８日后停药．对照组按常规剂量泼尼松每日ｌｍｇ／ｋｇ给药．结果试验组显效率及总有效率均优于对照组（Ｐ＜０．０５，＜０．０１）．治疗前后，用碱性磷酸酶抗碱性磷酸酶桥联酶标技术检查Ｔ淋巴细胞亚群．结果提示：ＩＴＰ患儿存在着Ｔ淋巴细胞免疫功能紊乱；泼尼松治疗ＩＴＰ通过抑制ＣＤ８＋来调节ＣＤ４＋／ＣＤ８＋比值，维持机体免疫功能的稳定；短期应用大剂量泼尼松对人体免疫功能的抑制作用与常规剂量相近．
This paper reports oral administration of large doses of prednisone in children with idiopathic thrombocytopenic purpura (ITP) 29 cases were randomly divided into experimental group of 15 cases and control group of 14 cases. The test group daily prednisone 8mg / kg, every 2 days, the dose was reduced to 6mg / kg daily, 4mg / kg, 2mg / kg, a total of 8 days after discontinuation. The control group was given conventional doses of prednisone lmg / kg daily. Results The effective rate and total effective rate of the experimental group were better than those of the control group (P <0.05, <0.01). Before and after treatment, with alkaline phosphatase anti-alkaline phosphatase enzyme-linked labeling of T lymphocyte subsets. The results suggest that: ITP children with T lymphocyte immune dysfunction; prednisone treatment of ITP by inhibiting CD8 + to regulate the ratio of CD4 / CD8, to maintain the stability of immune function; short-term high-dose prednisone on human immune function inhibition Similar effects and conventional dose.