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目的:总结单克隆抗体药物在抗血栓治疗中的应用及研究。方法:查找近年来国内外有关单克隆抗体药物临床应用及研究文献,做出汇总分析。结果:单克隆抗体药物主要从抑制血小板膜糖蛋白GPⅡb-Шa受体、血小板胶原受体(GPVI)及胶原-GPIb和胶原-vWF-GPIb轴等靶点起到抗凝溶栓作用,并在抗体导向溶栓治疗和血栓栓塞显像方面的研究有了一定的进展。结论:单克隆抗体药物在抗血栓治疗中取得了进展,但也存在一定的缺陷,有待进一步研究。
Objective: To summarize the application and research of anti-thrombotic therapy of monoclonal antibody drugs. Methods: To find out the clinical application and research literature about monoclonal antibody drugs at home and abroad in recent years, and make a summary analysis. RESULTS: Monoclonal antibody drugs mainly acted as anticoagulant and thrombolytic agents in inhibiting the GPⅡb-Шa receptor, platelet collagen receptor (GPVI) and the collagen-GPIb and collagen-vWF-GPIb axis of platelet glycoproteins, Antibody-directed thrombolytic therapy and thromboembolic imaging research has made some progress. Conclusion: Monoclonal antibody drugs have made some progress in the antithrombotic therapy, but there are some shortcomings, which need further study.