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应用替硝唑片口服治疗46例急性冠周炎患者,以甲硝唑片为对照组,检测了两组治疗前后盲袋内厌氧菌的变化及临床疗效。结果表明:替硝唑组和甲硝唑组对主要厌氧菌的杀菌率分别为91.8%和61.5%(P<0.01),对主要厌氧菌的抑菌率分别为94.6%和68.4%(P<0.01)。替硝唑组治疗急性冠周炎的临床疗效(有效率为80.4%)也优于甲硝唑组(有效率为37.5%)。因此,替硝唑应成为急性冠周炎患者全身给药时的首选药物。
46 patients with acute peri-peritonitis were treated with tinidazole tablets orally, and the changes of anaerobic bacteria in the blind bags before and after treatment were observed with metronidazole tablets as the control group. The results showed that the sterilization rates of the main anaerobic bacteria in the tinidazole group and the metronidazole group were 91.8% and 61.5% (P <0.01), respectively. The inhibition rates to the major anaerobic bacteria were 94.6% and 68.4% respectively (P <0.01). The clinical efficacy of tinidazole in the treatment of acute periarthritis (effective rate was 80.4%) was also superior to metronidazole group (effective rate was 37.5%). Therefore, tinidazole should be the drug of choice for systemic administration to patients with acute peri-periarthritis.