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目的:制备延胡索乙素柔性脂质体,研究其透皮吸收效果。方法:采用薄膜分散法制备延胡索乙素柔性脂质体,改良的Franz扩散池法研究其透皮吸收。结果:制备的延胡索乙素柔性脂质体包封率82.7%,粒径(112.3±59.2)nm,基本呈正态分布。该制剂12 h内累积渗透量2 121μg,明显高于对照组酊剂的1 153μg;在皮肤内滞留率53.9%,明显高于酊剂的11.2%。结论:制得的延胡索乙素柔性脂质体透皮效果较酊剂好。
Objective: Preparation of tetrahydropalmatine flexible liposomes, to study the transdermal absorption effect. Methods: Tetrahydropalmatine flexible liposomes were prepared by membrane dispersion method and the percutaneous absorption was studied by modified Franz diffusion cell method. Results: The encapsulation efficiency of the prepared tetrahydropalmatine flexible liposomes was 82.7% with a diameter of (112.3 ± 59.2) nm, which was basically normal distribution. The cumulative permeation amount of this preparation was 2 121 μg in 12 h, which was significantly higher than that of the control group (1 153 μg). The in-skin retention rate was 53.9%, which was significantly higher than that of the tincture (11.2%). Conclusion: The transdermal effect of the prepared tetrahydropalmatine flexible liposomes is better than tinctures.