合成将5-羟基-1,2,3,4-四氢异喹啉用甲酰胺在140℃下进行甲酰化反应,得N甲酰基-5-羟基-1,2,3,4-四氢异喹啉(Ⅲ),Ⅲ在水中通过NaOH与氯甲基环氧乙烷缩合得N-甲酰基-5-(2,3-环氧丙氧基)-1,2,3,4-四氢异喹啉(Ⅴ),最后将Ⅴ与特丁胺(Ⅵ)缩合即得。药理作用本品是一个强效的非亚型选择性的β肾上腺素能受体阻滞剂,不具内源性拟交感活性。尽管在体外结合试验和豚鼠兰根道尔夫氏心脏标本试验中,本品与心得 Synthesis 5-Hydroxy-1,2,3,4-tetrahydroisoquinoline was formylated with formamide at 140 ° C to give N-formyl-5-hydroxy-1,2,3,4-tetrakis Hydroisoquinoline (III), III is condensed in water with chloromethyloxirane via N-formyl-5- (2,3-epoxypropoxy) -1,2,3,4- Tetrahydroisoquinoline (V), and finally Ⅴ and tert-butylamine (Ⅵ) condensation derived. Pharmacological effects This product is a potent non-subtype of selective beta adrenergic receptor blockers, does not have endogenous sympathomimetic activity. Although in vitro and guinea pig Langen Randolph’s heart test, the product and experience