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目的探讨血清、尿β2-微球蛋白(β2-MG)和血清胱抑素C(Cys C)浓度在糖尿病肾病(DN)中的意义。方法测定60例单纯型糖尿病患者和45例糖尿病肾病患者血清、尿β2-微球蛋白和血清胱抑素C浓度,并与40名健康人群进行比较。结果糖尿病组和糖尿病肾病组β2-MG、Cys C均高于对照组(P<0.05),糖尿病肾病组β2-MG和Cys C均高于单纯型糖尿病组,差异均有统计学意义(P<0.01)。结论糖尿病患者β2-MG和Cys C浓度与糖尿病肾病密切相关,监测β2-MG和Cys C对于发现糖尿病患者早期肾功能损害有重要的临床意义。
Objective To investigate the significance of serum and urinary β2-microglobulin (β2-MG) and serum cystatin C (Cys C) in diabetic nephropathy (DN). Methods Serum and urinary β2-microglobulin and serum cystatin C concentrations were measured in 60 patients with simple diabetes mellitus and 45 patients with diabetic nephropathy, and compared with 40 healthy people. Results The levels of β2-MG and Cys C in diabetic group and diabetic nephropathy group were significantly higher than those in control group (P <0.05). The levels of β2-MG and Cys C in diabetic nephropathy group were significantly higher than those in simple diabetic group (P < 0.01). Conclusion The concentration of β2-MG and Cys C in diabetic patients is closely related to diabetic nephropathy. It is of great clinical significance to detect β2-MG and Cys C in the early stage of diabetic nephropathy.