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[目的 ]观察日本血吸虫病流行区人群血吸虫抗原 IFN- γ的应答特征。 [方法 ]选择江西省鄱阳湖中的南山岛上三个毗邻的自然村作为观察试区 ,根据粪检结果对 14～ 41岁人群按年龄组随机抽样 ,选取粪检结果阴性的 6 5人、粪检阳性的 6 4人为研究对象。采用全血培养法 ,检测培养上清中血吸虫抗原特异性的 IFN- γ水平 ,并检测血清中特异性抗体水平。 [结果 ]化疗后 ,人群 IFN-γ诱生水平较化疗前显著升高 ;未再感染组 SEA特异的 IFN-γ水平显著高于再感染组 ;SEA特异的 IFN -γ水平与抗 SEA的 Ig G4抗体水平之间呈显著负相关。 [结论 ]本研究结果提示 IFN-γ水平与对再感染的抗力有关
[Objective] To observe the response characteristics of human schistosome antigen IFN-γ in schistosomiasis japonica endemic areas. [Method] Three adjacent natural villages on Poyang Lake in Poyang Lake of Jiangxi Province were chosen as the observation area. According to the results of stool examination, the 14 ~ 41-year-old population were randomly selected according to the age groups. Sixty-five fecal negative specimens Sixty-four positive subjects were selected as research subjects. The whole blood culture method was used to detect the specific IFN-γ level of the schistosoma antigen in the culture supernatant and to detect the level of the specific antibody in the serum. [Results] After chemotherapy, the level of IFN-γ in the population was significantly higher than that before chemotherapy; the level of SEA-specific IFN-γ in non-re-infected group was significantly higher than that in re-infected group; the level of SEA-specific IFN- G4 antibody levels were significantly negatively correlated. [Conclusion] The results of this study suggest that the level of IFN-γ is related to the resistance to reinfection