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本文研究病人Disse间隙胶原和肝内压的相互关系,且探讨酒精引起大鼠肝肿大的可能结果。方法:70例每天饮80克酒精以上超过10年的嗜酒者。其中15例无肝病的临床或实验室证据,肝活检正常。其余55例中,光学显微镜检查15例仅有脂肪肝,9例有酒精性肝炎而无肝硬化,31例有肝硬化伴有或不伴肝炎。用Meng址ni针作肝活检前立即测量肝内间质压。以电子显微镜观察20至40个不同的Disse间隙。Disse间隙胶原记分分级如下:O示胶原正常或不存在;1+或2+示胶原成束出现,Disse间隙加宽,肝细胞微绒毛变平;3十示基膜形成;细胞间隙出现胶原加0 .5。光学显微镜下肝组织病变按坏死、炎症、Mal卜沉y小体、脂肪、末梢肝静脉硬化等各分1+~3+三级。 16只雄性Wistar大鼠,喂以含酒精(占热卡的36%)或蔗糖(各8只)的流汁饮食,计4周。乙醚浅麻醉下,在肝区作小切口。插入Clrib
This article studies the relationship between Disse interstitial collagen and intrahepatic pressure, and explores the possible consequences of alcohol-induced rat hepatomegaly. Methods: 70 cases of alcoholic drink more than 80 grams of alcohol a day more than 10 years. Of the 15 cases without clinical or laboratory evidence of liver disease, liver biopsy was normal. The remaining 55 cases, 15 cases of optical microscopy only fatty liver, 9 cases of alcoholic hepatitis without cirrhosis, 31 cases of cirrhosis with or without hepatitis. Meng site ni pin for liver biopsy immediately before measurement of interstitial pressure. 20 to 40 different Disse gaps were observed with an electron microscope. Disse interstitial collagen scoring grading as follows: O collagen showed normal or non-existent; 1+ or 2+ showed collagen bundles appeared, Disse gap widened, hepatocyte microvilli flattened; 3 ten base membrane formation; 0 .5. Light microscopic liver lesions by necrosis, inflammation, Mal Bu Shen y body, fat, peripheral hepatic venous sclerosis and other points 1 + ~ 3 + three. Sixteen male Wistar rats were fed a stream-fed diet containing alcohol (36% of calories) or sucrose (8 each) for 4 weeks. Ether light anesthesia, in the liver area for a small incision. Insert Clrib