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采用预防型大鼠脂质代谢紊乱模型法,以人体摄入量(2.6g/kg·bw)的10、20、30倍,作为低、中、高剂量组。采用SPF级Wistar大鼠经口灌胃,与模型对照组比较体重差异,比较胆固醇变化情况,比较甘油三酯变化情况,比较高密度脂蛋白胆固醇变化情况。结果表明大鼠体重明显低于模型对照组,差异有显著性;胆固醇含量下降幅度分别为45.0%、16.2%、8.0%;甘油三酯含量下降幅度分别为32.2%、21.0%、3.4%;高剂量组对高密度脂蛋白胆固醇有升高作用。从而说明共轭亚油酸有明显的调节血脂作用。
The preventive model of lipid metabolism in rats was adopted as the low, medium and high dose groups at 10, 20 and 30 times of the human body intake (2.6g / kg · bw) respectively. The SPF Wistar rats were orally administered orally, compared with the model control group body weight differences, changes in cholesterol were compared to compare changes in triglycerides, comparing the changes of high-density lipoprotein cholesterol. The results showed that the body weight of rats was significantly lower than the model control group, the difference was significant; the cholesterol content decreased by 45.0%, 16.2% and 8.0% respectively; the decrease of triglyceride content was 32.2%, 21.0% and 3.4% respectively; The dose group had an elevated effect on high-density lipoprotein cholesterol. Conjugated linoleic acid thus shows a significant role in regulating blood lipids.