论文部分内容阅读
糖尿病肾病（DN）是导致终末期肾衰的常见病因之一，该病在早期即出现以肾小球高滤过、高灌注为特点的肾小球肥大，其机制尚不十分清楚。一氧化氮（NO）是影响肾小球血流动力学变化的一种生物活性物质，我们将采用链豚佐菌素（STZ）诱导的糖尿病大鼠模型对此进行研究。材料和方
Diabetic nephropathy (DN) is one of the most common causes of end-stage renal failure. Glomerular hypertrophy, characterized by hyperfiltration and hyperperfusion of glomeruli, occurs at an early stage and its mechanism is not well understood. Nitric oxide (NO) is a bioactive substance that affects the glomerular hemodynamic changes and we will investigate this using streptozotocin (STZ) -induced diabetic rat model. Material and side