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目的 前瞻性研究骨髓外组织检出海蓝组织细胞的特点及意义。方法 对临床上所有进行穿刺及脱落细胞学检查的标本同时做H -E染色和瑞氏 -姬姆萨染色 ,然后镜检查找海蓝组织细胞。对被检出海蓝组织细胞的患者再行骨髓穿刺检查 ,确认骨髓中是否也有海蓝组织细胞。临床上重点观察其有无肝、脾肿大、皮肤有无出血斑、BPC是否减少。结果 从 5 76 0例被检标本中检出海蓝组织细胞 8例 ,此 8例患者骨髓中未见海蓝组织细胞 ,临床上无肝、脾肿大 ,皮肤无出血斑 ,BPC无减少。结论 骨髓外检出海蓝组织细胞的患者临床表现与“海蓝组织细胞增生症”不同 ,可能为骨髓外局部组织海蓝组织细胞增生的缘故 ,认为骨髓外组织也可分化产生海蓝组织细胞
Objective To prospectively study the characteristics and significance of detecting extracellular matrix of melanocytes in extramedullary tissue. Methods H-E staining and Wright-Giemsa staining were performed simultaneously on all the specimens that were punctured and exfoliated cytologically. Then the cells were examined by microscopic examination. On the detection of melanoma cells in patients with bone marrow biopsy again to confirm whether the bone marrow also have blue tissue cells. Clinical focus of its presence or absence of liver, splenomegaly, whether the skin bleeding spots, BPC is reduced. Results There were 8 cases of melanoma cells in 5 76 0 specimens. None of the 8 cases had melanocyte in the bone marrow. There was no liver, splenomegaly and no bleeding spots on the skin, but no decrease of BPC. Conclusion The clinical manifestations of patients with extramedullary hematopoietic cells detected by extramedullary marrow are different from those of “hernocytosis”, which may be due to hyperplasia of extramedullary tissue in the extramedullary tissue.