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为研究新生儿硬肿症酸碱紊乱的发生情况，对３９例新生儿硬肿症患者进行血气分析和阴离子间隙（ＡＧ值）测定。结果示８４．６％存在酸碱紊乱，其中８１．８％为代谢性酸中毒，高ＡＧ代酸占７０．４％；％重酸碱紊乱占２３．１％，新生儿硬肿症酸碱紊乱及高ＡＧ代酸的发生率与有无合并症，体重高低无关（Ｐ＞０．０５），而与硬肿程度有关（Ｐ＜０．０１，Ｐ＜０．０５），但有合并症的硬肿症与单纯寒冷损伤其双重酸碱紊乱的发生率相差显著（Ｐ＜０．０５）。说明硬肿症患儿由于微循环障碍，全身主要脏器的代谢功能发生改变，是造成酸碱紊乱和高ＡＧ代酸的基础，而存在合并症将使酸碱紊乱变得更加错综复杂。ＡＧ值的测定对治疗有指导作用。建议硬肿症患儿应常规查血气和ＡＧ值，避免盲目补碱。
In order to study the occurrence of acid-base disorder in neonates with sclerosis, blood gas analysis and anion gap (AG value) were measured in 39 neonates with sclerema. The results showed 84.6% acid-base disorders, of which 81.8% of metabolic acidosis, high AG substitution acid accounted for 70.4%;% heavy acid and acid disorders accounted for 23.1%, neonatal sclerosing acid The incidence of disorganization and high AG acidosis was not related to the presence or absence of comorbidity and body weight (P> 0.05), but was related to the degree of sclerosis (P <0.01, P <0.05) (P <0.05). The difference between the two groups was significant (P <0.05). Description of children with sclerema due to microcirculation, metabolic changes in the main organs of the body is caused by acid-base disorders and the basis of high AG acid, and the presence of complications will make the acid-base disorders become more complex. Determination of AG value has a guiding role in the treatment. Recommended scleredemia children should routinely check blood gas and AG values, to avoid blind alkali.