本文比较了四环素,脱水四环素,叉向四环素及脫水叉向四环素的毒性。急性毒性以叉向四环素为最大,小白鼠靜脉LD_(50)为85.8毫克/公斤,而四环素,脫水四环素及脫水叉向四环素的LD_(50)分別为160.7毫克/公斤,134.2毫克/公斤及193毫克/公斤。亚急性毒性则以脫水叉向四环素为最大,小白鼠不论靜脉注射1毫克/0.5毫升或口服12毫克/0.2毫升,均能出现较重的糖尿及蛋白尿,肾曲管发生较重的病变,可能是临床引起Fanconi症候羣的主要物质。 This article compares the toxicity of tetracycline, dehydrated tetracycline, tetracycline to tetracycline, and dehydration to tetracycline. Acute toxicity to tetracycline for the maximum, white mice intravenous LD_ (50) of 85.8 mg / kg, and tetracycline, dehydrated tetracycline and dehydrated fork to tetracycline LD_ (50) were 160.7 mg / kg, 134.2 mg / kg and 193 Mg / kg. Subacute toxicity to dehydration fork to tetracycline maximum, mice regardless of intravenous injection of 1 mg / 0.5 ml or oral 12 mg /0.2 ml, can occur in severe diabetes and proteinuria, renal tubulosclerosis occurred heavier, May be the main cause of Fanconi syndrome clinically.