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结核病是全球范围内疾病负担最严重的疾病之一,结核病控制工作已成为重大的公共卫生问题与社会问题,尽管结核病的防治工作取得积极成效,但仍面临诸多挑战[1-2]。据报道,世界约有1/3的人口感染结核分枝杆菌,仅有不足1/10的结核病分枝杆菌感染者继续发展成为临床结核病患者,其他大多数感染者均能控制或清除体内的结核分枝杆菌[3-4]。提示结核病的发病存在个体差异,可能与
Tuberculosis is one of the most serious disease burden in the world. Tuberculosis control has become a major public health and social problem. Although tuberculosis prevention and treatment work has achieved positive results, it still faces many challenges [1-2]. It is reported that about one-third of the world’s population is infected with Mycobacterium tuberculosis, and less than one in 10 cases of Mycobacterium tuberculosis infection continues to develop as clinical TB patients. Most other infected persons can control or clear TB in the body Mycobacterium [3-4]. Tip tuberculosis incidence of individual differences may be