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尸检与动物缺血模型获取的神经细胞学资料表明,中枢神经系统生长与修复因子之一的成纤维细胞生长因子(FGF)在脑缺血梗塞后脑细胞增生与修复中起到重要调节作用。主要参与以下过程:(1)巨噬细胞增生;(2)神经胶质细胞,包括星形胶质细胞、少突胶质细胞的增生;(3)新生血管。本研究认为脑损伤后缺血诱发室管膜FGF释放到脑脊液内。 FGF家族包括7种结构相关的多肽,其中酸性与碱性FGF被完善地鉴定。FGF普遍存在于各种神经组织中,尤以室管膜细胞最多。在正常成人,FGF能维持各种类型神经元存活,是神经系统发
Neurocytology data obtained from autopsy and animal models of ischemia indicate that FGF, one of the central nervous system growth and repair factors, plays an important regulatory role in the proliferation and repair of brain cells after cerebral infarction. Mainly involved in the following processes: (1) macrophage hyperplasia; (2) glial cells, including astrocytes, oligodendrocyte proliferation; (3) neovascularization. This study suggests that ischemia-induced ependymal FGF release into cerebrospinal fluid after brain injury. The FGF family includes seven structurally related polypeptides, of which the acidic and basic FGFs are well characterized. FGF is ubiquitous in a variety of nerve tissue, especially ependymal cells. In normal adults, FGF can maintain the survival of various types of neurons, is the nervous system hair